Solomon J B
Immunology. 1966 Aug;11(2):89-96.
The formation of antibody to goat erythrocytes has been studied in embryos and young chicks. Opsonizing antibody was measured by accelerated clearance of antigen and the sensitivity of this technique compared with haemagglutination tests. A wide range of immunizing doses of goat erythrocytes was used; all induced immunity. Small amounts of antibody were detected as early as the day of hatching but vigorous antibody production did not occur until 3 days later. An immune response could be induced in 12-day-old embryos and the most vigorous response was obtained by injection of 14-day-old embryos. Antibody production was relatively poor between the fifteenth day of embryonic life and 15 days after hatching. This was due to the presence of maternal antibody.
对胚胎和幼雏体内抗山羊红细胞抗体的形成进行了研究。通过抗原清除加速来测定调理素抗体，并将该技术的灵敏度与血凝试验进行比较。使用了多种免疫剂量的山羊红细胞；所有剂量均诱导产生了免疫。早在孵化当天就检测到少量抗体，但直到3天后才出现强烈的抗体产生。在12日龄胚胎中可诱导产生免疫反应，而通过注射14日龄胚胎可获得最强烈的反应。在胚胎期第15天至孵化后15天之间，抗体产生相对较少。这是由于母体抗体的存在。
