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与凝聚素反应的醛化中间体的制备及其性质。I. 豚鼠补体。

The preparation and properties of alexinated intermediates that react with conglutinin. I. Guinea-pig complement.

作者信息

Lachmann P J, Liske R

出版信息

Immunology. 1966 Sep;11(3):243-54.

PMID:5922092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423791/
Abstract

Evidence has been advanced confirming earlier work that conglutinin reacts solely with a determinant exposed in fixed C′. The reactivity is not influenced by the decay of earlier components or the activity of later ones. Heterologous sources of C′ (rabbit and human) reacting with guinea-pig EAC′ give conglutinable intermediates. The stability of EAC′ for conglutination is much greater than for lysis. The study of decayed intermediates which still react with conglutinin suggests that the bulk of the C′ fixed has after some time no haemolytic function. Possible explanations of this phenomenon are discussed. The `long-term' functions of the bulk of the fixed C′ may therefore be associated with manifestations of complement activities other than haemolysis.

摘要

已有证据证实了早期的研究工作，即凝集素仅与固定补体C′中暴露的一个决定簇发生反应。这种反应性不受早期成分衰变或后期成分活性的影响。与豚鼠EAC′反应的异源补体C′（兔和人）可产生可被凝集的中间体。EAC′对凝集的稳定性远高于对溶解的稳定性。对仍与凝集素反应的衰变中间体的研究表明，大部分固定的C′在一段时间后不再具有溶血功能。本文讨论了这一现象的可能解释。因此，大部分固定C′的“长期”功能可能与除溶血以外的补体活性表现相关。

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引用本文的文献

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2
A sedimentation pattern technique for measuring conglutination: its application to demonstrating immunoconglutinins to C'4.一种用于测量凝集反应的沉降模式技术：其在证明针对C'4的免疫凝集素中的应用。
Immunology. 1966 Sep;11(3):263-71.
3
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Immunoconglutinins of different immunoglobulin classes demonstrated by the antiglobulin reaction.通过抗球蛋白反应显示的不同免疫球蛋白类别的免疫胶固素。
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本文引用的文献

1
Isolation and description of proteins related to the human complement system.与人类补体系统相关蛋白质的分离与描述。
Acta Soc Med Ups. 1961;66:152-70.
2
COMPONENTS OF GUINEA PIG COMPLEMENT. I. SEPARATION OF A SERUM FRACTION ESSENTIAL FOR IMMUNE HEMOLYSIS AND IMMUNE ADHERENCE.豚鼠补体的成分。I. 免疫溶血和免疫黏附所必需的血清成分的分离。
J Exp Med. 1963 Nov 1;118(5):767-93. doi: 10.1084/jem.118.5.767.
3
A comparison of some properties of bovine conglutinin with those of rabbit immuno-conglutinin.牛胶固素与兔免疫胶固素某些特性的比较。
Immunology. 1962 Nov;5(6):687-705.
4
A possible homeostatic mechanism in complement fixation: inhibition of the activity of fixed C'1 by the fixation of C'3a.补体固定中一种可能的稳态机制：C'3a的固定对已固定C'1活性的抑制。
Nature. 1966 Apr 9;210(5032):140-1. doi: 10.1038/210140a0.
5
A sedimentation pattern technique for measuring conglutination: its application to demonstrating immunoconglutinins to C'4.一种用于测量凝集反应的沉降模式技术：其在证明针对C'4的免疫凝集素中的应用。
Immunology. 1966 Sep;11(3):263-71.
6
Multiple nature of the third component of guinea-pig complement. II. Separation and description of two additional factors beta and d; preparation and characterization of four intermediate products.豚鼠补体第三成分的多重性质。II. 另外两个因子β和δ的分离与描述；四种中间产物的制备与特性分析
Immunology. 1965 Jun;8(6):604-17.
7
Multiple nature of the third component of guinea-pig complement. I. Separation and characterization of three factors a, b, and c, essential for haemolysis.豚鼠补体第三成分的多重性质。I. 溶血所必需的三种因子a、b和c的分离与特性鉴定。
Immunology. 1965 Jun;8(6):590-603.

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