小鼠伤寒中的宿主-寄生虫关系。
Host-parasite relations in mouse typhoid.
作者信息
Mackaness G B, Blanden R V, Collins F M
出版信息
J Exp Med. 1966 Oct 1;124(4):573-83. doi: 10.1084/jem.124.4.573.
Abstract
The development of acquired resistance to Salmonella typhimurium has been studied in mice infected intravenously with small numbers of streptomycin-sensitive or streptomycin-resistant organisms. By the 14th day of a primary infection the mouse develops a mechanism capable of destroying completely a super infecting dose of organisms, but is unable to eliminate organisms of the primary infection. The latter are constantly returned to the circulation from necrotic foci at the sites of implantation. Passive transfer of serum from actively infected or vaccinated animals, and immunization with heat-killed organisms, increase the capacity of the host to clear organisms from the blood, but do not interfere to any significant extent with their subsequent multiplication in the tissues. It is concluded that the resistance of actively infected animals depends on a nonhumoral mechanism capable of destroying organisms from endogenous or exogenous sources.
摘要
已经在静脉内感染少量链霉素敏感或链霉素抗性鼠伤寒沙门氏菌的小鼠中研究了获得性耐药性的发展。在初次感染的第14天，小鼠形成了一种能够完全破坏超感染剂量细菌的机制，但无法清除初次感染的细菌。后者不断从植入部位的坏死灶返回循环系统。来自主动感染或接种疫苗动物的血清的被动转移以及用热灭活细菌进行免疫，可增加宿主从血液中清除细菌的能力，但在很大程度上不会干扰它们随后在组织中的繁殖。得出的结论是，主动感染动物的抗性取决于一种能够破坏内源性或外源性细菌的非体液机制。
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