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吞咽困难:贲门失弛缓症的一种变体或早期阶段?

Dyschalasia: a variant or early phase of Achalasia?

作者信息

Beck I T, Hernandez N A, Solymar J

出版信息

Can Med Assoc J. 1966 Nov 5;95(19):941-6.

PMID:5922908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1935748/
Abstract

One of the characteristic motor abnormalities in achalasia of the esophagus is the lack of relaxation of the lower esophageal sphincter during swallowing. In a subject with a clinical history and radiologic evidence of early achalasia all the typical motor abnormalities of the disease were observed in the course of pressure studies, but the sphincter exhibited a fall of pressure in response to a contraction of the body of the esophagus. This relaxation occurred later than would be expected in the normal esophagus and, therefore, this unusual condition was named dyschalasia.The relationship of dyschalasia to classical achalasia is discussed and several theories are advanced. The authors believe that dyschalasia is possibly an early stage of achalasia.

摘要

食管贲门失弛缓症的典型运动异常之一是吞咽时食管下括约肌缺乏松弛。在一名有早期贲门失弛缓症临床病史和放射学证据的受试者中,在压力研究过程中观察到了该疾病所有典型的运动异常,但括约肌在食管体部收缩时出现压力下降。这种松弛比正常食管预期的时间要晚,因此,这种异常情况被命名为吞咽困难。本文讨论了吞咽困难与典型贲门失弛缓症的关系,并提出了几种理论。作者认为吞咽困难可能是贲门失弛缓症的早期阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d8a/1935748/3eaba2eccbfc/canmedaj01189-0006-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d8a/1935748/c3f126e3c84d/canmedaj01189-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d8a/1935748/3eaba2eccbfc/canmedaj01189-0006-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d8a/1935748/c3f126e3c84d/canmedaj01189-0006-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d8a/1935748/3eaba2eccbfc/canmedaj01189-0006-b.jpg

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1
Dyschalasia: a variant or early phase of Achalasia?吞咽困难:贲门失弛缓症的一种变体或早期阶段?
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引用本文的文献

1
Does diffuse esophageal spasm progress to achalasia? A prospective cohort study.弥漫性食管痉挛会进展为贲门失弛缓症吗?一项前瞻性队列研究。
Dig Dis Sci. 2005 Sep;50(9):1605-10. doi: 10.1007/s10620-005-2903-3.
2
Unclassified oesophageal motor disorders simulating achalasia.疑似贲门失弛缓症的未分类食管运动障碍。
Gut. 1969 Mar;10(3):234-40. doi: 10.1136/gut.10.3.234.
3
Possible pathogenesis of motility changes in diffuse esophageal spasm associated with gastric carcinoma.与胃癌相关的弥漫性食管痉挛中运动变化的可能发病机制。

本文引用的文献

1
The chemical transmitter of vagus effects to the stomach.迷走神经对胃产生作用的化学递质。
J Physiol. 1934 Jun 9;81(3):320-34. doi: 10.1113/jphysiol.1934.sp003138.
2
Acetylcholine synthesis in different regions of the central nervous system.中枢神经系统不同区域的乙酰胆碱合成。
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Pathologic changes in megaesophagus (esophageal dystonia).巨食管(食管张力障碍)的病理变化。
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Esophageal sensitivity to mecholyl in cardiospasm.贲门失弛缓症时食管对乙酰甲胆碱的敏感性
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ACHALASIA OF THE ESOPHAGUS: PATHOLOGIC AND ETIOLOGIC CONSIDERATIONS.食管贲门失弛缓症:病理学及病因学考量
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6
TREATMENT OF ACHALASIA OF THE CARDIA WITH PNEUMATIC DILATIONS.贲门失弛缓症的气囊扩张治疗
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Esophageal motility after vagotomy, phrenicotomy, myotomv. and mvomectomv in dogs.犬迷走神经切断术、膈神经切断术、肌切开术和肌切除术术后的食管动力
Surg Gynecol Obstet. 1962 Jan;114:31-42.
9
Physiological observations in achalasia and their significance in methods of treatment.贲门失弛缓症的生理学观察及其在治疗方法中的意义。
Gastroenterologia. 1959;92:114-23. doi: 10.1159/000202881.
10
Segmental response of the inferior esophageal sphincter to elevated intragastric pressure.
Gastroenterology. 1961 Mar;40:405-7.