Dibenztroponeacetic and -propionic acids. Potent new antiinflammatory agents.
作者信息
Dunn J P, Green D M, Nelson P H, Rooks W H, Tomolonis A, Untch K G
出版信息
J Med Chem. 1977 Dec;20(12):1557-62. doi: 10.1021/jm00222a004.
PMID:592320
Abstract
The syntheses and antiinflammatory assays of some dibenztroponeacetic and -propionic acids and derivatives are described. The most potent compound, d-2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionic acid, has a potency of ca, 70 times phenylbutazone in the rat carrageenan paw assay and two to three times indomethacin in long-term animal assays. Some beta-dialkylaminoethyl esters of this compound also show high antiinflammatory activity.
摘要
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