潜在的抗炎化合物。1. 抗炎苯基哌啶衍生物。
Potential antiinflammatory compounds. 1. Antiinflammatory phenylpiperidine derivatives.
作者信息
Hicks T A, Smith C E, Williamson W R, Day E H
出版信息
J Med Chem. 1979 Dec;22(12):1460-4. doi: 10.1021/jm00198a006.
PMID:536991
Abstract
The syntheses of a number of amines and their derivatives, based on the phenylpiperidine nucleus, are described. Their activities on the rat paw carrageenan test are also reported. Activities comparable to that of phenylbutazone were obtained for some of the amines, notably 4-piperidino-beta-methylphenethylamine.
摘要
本文描述了一系列基于苯哌啶核的胺及其衍生物的合成方法。同时也报道了它们在大鼠足爪角叉菜胶试验中的活性。部分胺类化合物，尤其是4-哌啶基-β-甲基苯乙胺，展现出了与保泰松相当的活性。
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