Khosla S N, Srivastava S C, Gupta S
J Trop Med Hyg. 1977 May;80(5):95-8.
The clinical pattern of typhoid fever is changing, and in particular the incidence of neuro-psychiartic manifestations is on the increase. In 246 cases of enteric fever we found 124 with confusional states, delirium, coma, generalized myoclonus, Parkinsonian rigidity or psychoses. We further distinguished two major sub-groups with an acute and an insidious onset. The apparent increase in the frequency of neuro-psychiatric complications of typhoid could represent a change in the pathogenicity of S. typhi or the increasing recognition of a biochemical defect caused by a bacterial endotoxins and provoked by poor nutrition.
伤寒热的临床症状正在发生变化，尤其是神经精神症状的发生率在上升。在246例伤寒病例中，我们发现124例出现意识模糊状态、谵妄、昏迷、全身性肌阵挛、帕金森氏强直或精神病症状。我们进一步区分出两个主要亚组，分别为急性起病和隐匿起病。伤寒神经精神并发症发生率的明显上升，可能代表伤寒杆菌致病性的改变，或者是对由细菌内毒素引起并因营养不良而诱发的生化缺陷认识的增加。
