温度对由内毒素和病毒诱导干扰素的影响。
Effect of temperature on the induction of interferons by endotoxin and virus.
作者信息
Postic B, DeAngelis C, Breinig M K, Monto H O
出版信息
J Bacteriol. 1966 Mar;91(3):1277-81. doi: 10.1128/jb.91.3.1277-1281.1966.
Postic, Bosko (University of Pittsburgh, Pittsburgh, Pa.), Catherine DeAngelis, Mary K. Breinig, and Monto Ho. Effect of temperature on the induction of interferons by endotoxin and virus. J. Bacteriol. 91:1277-1281. 1966.-The effect of ambient and body temperature on interferon formation in rabbits injected intravenously with virus differed from that seen after injection of endotoxin. Newcastle disease virus-induced interferon (VII) was elevated by increasing ambient temperature to 35 C, whereas cooling of the rabbit at 4 C resulted in low VII levels. Neither of these conditions affected the titers of endotoxin-induced interferon (EII). However, a significant enhancement of EII levels was found in sera of shorn rabbits, in which the body temperature was lower than in unshorn animals by 1.0 to 1.5 F and the pyrogenic response to endotoxin was less by about 2 F. This enhancement of EII by relatively low body temperatures was also in striking contrast to the reported enhancing effect of high body temperature of the rabbit on the lethal action of endotoxin. It is suggested that the temperature optimum for formation of EII is lower than for formation of VII.
波斯蒂奇，博斯科（匹兹堡大学，宾夕法尼亚州匹兹堡），凯瑟琳·迪安吉利斯，玛丽·K·布雷宁，以及蒙托·霍。温度对内毒素和病毒诱导干扰素的影响。《细菌学杂志》91:1277 - 1281。1966年。——环境温度和体温对静脉注射病毒的家兔体内干扰素形成的影响与注射内毒素后的情况不同。将环境温度升高到35℃可使新城疫病毒诱导的干扰素（VII）升高，而将家兔冷却至4℃会导致VII水平较低。这两种情况均未影响内毒素诱导的干扰素（EII）的效价。然而，在剪毛的家兔血清中发现EII水平显著升高，其体温比未剪毛的动物低1.0至1.5华氏度，对内毒素的热原反应也低约2华氏度。相对较低的体温对EII的这种增强作用也与报道的家兔高温对内毒素致死作用的增强效应形成鲜明对比。有人提出，EII形成的最适温度低于VII形成的最适温度。
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