McLean D M, Coleman M A, Larke R P, McNaughton G A
Can Med Assoc J. 1966 Apr 16;94(16):839-43.
Enteroviruses were isolated from feces and/or cerebrospinal fluid of 29 of 43 Toronto children who contracted aseptic meningitis, pleurodynia, abdominal pain or febrile upsets between June and October, 1965. Coxsackie A9 virus was the dominant agent in aseptic meningitis and Coxsackie B1 virus in pleurodynia and other syndromes. Sero-logical evidence of recent Coxsackie B1 and Echo 6 infection was obtained in two additional patients with aseptic meningitis who did not yield virus, and elevated Coxsackie B1 antibody titres were found in one patient with pericarditis. A newborn infant died with myocarditis due to Coxsackie B1 virus following infection of the mother during the immediate antenatal period. Paired sera collected only two to four days apart from patients with enteroviral syndromes or mumps meningoencephalitis frequently showed four-fold or greater increases of antibody levels.
1965年6月至10月期间，从43名患无菌性脑膜炎、胸膜痛、腹痛或发热不适的多伦多儿童中的29名儿童的粪便和/或脑脊液中分离出肠道病毒。柯萨奇A9病毒是无菌性脑膜炎的主要病原体，柯萨奇B1病毒是胸膜痛和其他综合征的主要病原体。另外两名无菌性脑膜炎患者未分离出病毒，但获得了近期柯萨奇B1和埃可病毒6感染的血清学证据，一名心包炎患者的柯萨奇B1抗体滴度升高。一名新生儿在母亲临产前感染柯萨奇B1病毒后死于心肌炎。从患有肠道病毒综合征或腮腺炎脑膜脑炎的患者中仅相隔两到四天采集的配对血清，抗体水平经常显示出四倍或更大的升高。
