McLean D M, Larke R P, Cobb C, Griffis E D, Hackett S M
Can Med Assoc J. 1967 May 20;96(20):1355-61.
Of 52 children admitted to hospital for apparently typical mumps meningitis in 1966, 50 had their cerebrospinal fluid (CSF) examined. In only 17 was the mumps virus isolated from the CSF. Mumps antihemagglutinin conversions or increments were detected in 32 subjects including 10 whose CSF yielded virus. Antibody conversions were found in 16 patients and fourfold increments in another nine whose serum pairs were collected only one to four days apart. Initial sera from 20 patients were obtained three days or less after the onset of meningitis. Antibody increments were frequently noted about one day after defervescence and clinical improvement. Interferon was detected in CSF from two of eight patients, both of whom yielded virus. Enteroviruses were isolated from CSF and/or feces in seven of 15 cases of aseptic meningitis which occurred between July and October. Six patients including three virus excretors showed enteroviral neutralizing antibody increments during convalescence. The dominant enteroviral serotype was coxsackievirus A9.
1966年，52名因明显典型的腮腺炎脑膜炎入院的儿童中，50名接受了脑脊液（CSF）检查。仅17名儿童的脑脊液中分离出腮腺炎病毒。32名受试者检测到腮腺炎抗血凝素转化或增加，其中10名受试者的脑脊液分离出病毒。16名患者发现抗体转化，另外9名患者血清样本采集间隔仅1至4天，抗体呈四倍增加。20名患者的初始血清在脑膜炎发病后3天或更短时间内获得。发热消退和临床改善后约1天经常观察到抗体增加。8名患者中有2名脑脊液检测到干扰素，这两名患者均分离出病毒。7月至10月期间发生的15例无菌性脑膜炎中，15例中有7例脑脊液和/或粪便中分离出肠道病毒。6名患者包括3名病毒排泄者在康复期间肠道病毒中和抗体增加。主要的肠道病毒血清型是柯萨奇病毒A9。
