地昔帕明和其他一些抗抑郁药物会降低大鼠脑中主要去甲肾上腺素代谢物3,4 -二羟基苯乙二醇硫酸盐的含量。 - Suppr

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Desipramine and some other antidepressant drugs decrease the major norepinephrine metabolite 3,4-dihydroxyphenylglycol-sulphate in the rat brain.

作者信息

Nielsen M, Braestrup C

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):93-9. doi: 10.1007/BF00505084.

DOI:10.1007/BF00505084

PMID:593431

Abstract

摘要

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Desipramine and some other antidepressant drugs decrease the major norepinephrine metabolite 3,4-dihydroxyphenylglycol-sulphate in the rat brain.

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Chronic treatment with desipramine caused a sustained decrease of 3,4-dihydroxyphenylglycol-sulphate and total 3-methoxy-4-hydroxyphenylglycol in the rat brain.

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CLINICAL PHARMACOLOGY OF IMIPRAMINE AND RELATED ANTIDEPRESSANT COMPOUNDS.

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A method for the assay of conjugated 3,4-dihydroxyphenylglycol, a major noradrenaline metabolite in the rat brain.

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