Charney D S, Breier A, Jatlow P I, Heninger G R
Psychopharmacology (Berl). 1986;88(2):133-40. doi: 10.1007/BF00652229.
The effect of single doses of alprazolam (1.5 mg) and yohimbine (30 mg) and alprazolam and yohimbine given together on plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), cortisol, blood pressure, and subjective behavioral ratings was studied in eight healthy subjects. In comparison to placebo, alprazolam significantly reduced plasma MHPG and cortisol, systolic and diastolic blood pressure, and increased subjective ratings of drowsiness and mellow. Yohimbine and the alprazolam-yohimbine combination significantly increased plasma free MHPG. Concomitant yohimbine administration antagonized the effects of alprazolam on blood pressure and attenuated alprazolam-induced changes in cortisol and subjective ratings. The ability of alprazolam to decrease plasma MHPG and blood pressure contrasts with previously reported effects of diazepam. The implications of the findings of the present investigation to the postulated role of brain noradrenergic function in the etiology of panic anxiety and the therapeutic mechanism of action of antipanic treatment are discussed.
在8名健康受试者中研究了单剂量阿普唑仑（1.5毫克）、育亨宾（30毫克）以及阿普唑仑与育亨宾联合使用对血浆游离3-甲氧基-4-羟基苯乙二醇（MHPG）、皮质醇、血压和主观行为评分的影响。与安慰剂相比，阿普唑仑显著降低了血浆MHPG和皮质醇、收缩压和舒张压，并提高了嗜睡和放松的主观评分。育亨宾以及阿普唑仑-育亨宾组合显著提高了血浆游离MHPG。同时给予育亨宾可拮抗阿普唑仑对血压的作用，并减弱阿普唑仑引起的皮质醇和主观评分变化。阿普唑仑降低血浆MHPG和血压的能力与先前报道的地西泮的作用形成对比。讨论了本研究结果对大脑去甲肾上腺素能功能在惊恐焦虑病因学中假定作用以及抗惊恐治疗作用机制的意义。
