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Chronic treatment with desipramine caused a sustained decrease of 3,4-dihydroxyphenylglycol-sulphate and total 3-methoxy-4-hydroxyphenylglycol in the rat brain.

作者信息

Nielsen M, Braestrup C

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):87-92. doi: 10.1007/BF00505083.

DOI:10.1007/BF00505083
PMID:593430
Abstract
摘要

相似文献

1
Chronic treatment with desipramine caused a sustained decrease of 3,4-dihydroxyphenylglycol-sulphate and total 3-methoxy-4-hydroxyphenylglycol in the rat brain.用去甲丙咪嗪进行长期治疗导致大鼠脑中3,4-二羟基苯乙二醇硫酸盐和总3-甲氧基-4-羟基苯乙二醇持续减少。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):87-92. doi: 10.1007/BF00505083.
2
Desipramine and some other antidepressant drugs decrease the major norepinephrine metabolite 3,4-dihydroxyphenylglycol-sulphate in the rat brain.地昔帕明和其他一些抗抑郁药物会降低大鼠脑中主要去甲肾上腺素代谢物3,4 -二羟基苯乙二醇硫酸盐的含量。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):93-9. doi: 10.1007/BF00505084.
3
The effect of acute and chronic desipramine and amitriptyline treatment on rat brain total 3methoxy-4-hydroxyphenylglycol.急性和慢性地昔帕明及阿米替林治疗对大鼠脑总3-甲氧基-4-羟基苯乙二醇的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):207-11. doi: 10.1007/BF00498812.
4
Effects of intraventricular injections of 6-hydroxydopamine on amine metabolites in rat brain and urine.脑室内注射6-羟基多巴胺对大鼠脑和尿中胺类代谢产物的影响。
Biochem Pharmacol. 1985 Apr 15;34(8):1255-63. doi: 10.1016/0006-2952(85)90503-9.
5
Reduced metabolism and turnover rates of rat brain dopamine, norepinephrine and serotonin by chronic desipramine and zimelidine treatments.长期使用去郁敏和齐美利定治疗可降低大鼠脑内多巴胺、去甲肾上腺素和5-羟色胺的代谢及周转速率。
Eur J Pharmacol. 1984 Apr 20;100(2):137-44. doi: 10.1016/0014-2999(84)90215-2.
6
Interaction of antidepressants with clonidine on rat brain total 3-methoxy-4-hydroxyphenylglycol.抗抑郁药与可乐定对大鼠脑总3-甲氧基-4-羟基苯乙二醇的相互作用。
Can J Physiol Pharmacol. 1979 Apr;57(4):435-7. doi: 10.1139/y79-067.
7
Effect of acute and chronic treatment with tricyclic antidepressants on 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) contents in various regions of rat brain.三环类抗抑郁药急性和慢性治疗对大鼠脑不同区域3-甲氧基-4-羟基苯乙二醇硫酸盐（MHPG-SO4）含量的影响。
Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(2):137-42. doi: 10.1016/s0278-5846(82)80189-9.
8
Effects of single and multiple doses of desipramine (DMI) on endogenous levels of 3-methoxy-4-hydroxyphenylglycol-sulfate (MOPEG-SO4) in rat brain.单次及多次给予地昔帕明（DMI）对大鼠脑内3-甲氧基-4-羟基苯乙二醇硫酸盐（MOPEG-SO4）内源性水平的影响。
Eur J Pharmacol. 1978 Aug 15;50(4):301-6. doi: 10.1016/0014-2999(78)90135-8.
9
The effect of amitriptyline, desipramine and imipramine on the vivo brain synthesis of 3H-noradrenaline from 3H-L-dopa in the rat.阿米替林、去甲丙咪嗪和丙咪嗪对大鼠体内由3H-L-多巴合成3H-去甲肾上腺素的影响。
Psychopharmacologia. 1975;41(3):249-54. doi: 10.1007/BF00428932.
10
Effects of acutely and chronically administered antidepressants on the brain regional 3-methoxy-4-hydroxyphenylethyleneglycol sulfate in the forced swimming rat.急性和慢性给予抗抑郁药对强迫游泳大鼠脑区硫酸3-甲氧基-4-羟基苯乙二醇的影响。
Life Sci. 1981 Nov 2;29(18):1921-8. doi: 10.1016/0024-3205(81)90525-7.

引用本文的文献

1
Chronic treatment with some atypical antidepressants increases the brain level of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rats.用某些非典型抗抑郁药进行长期治疗会提高大鼠大脑中3-甲氧基-4-羟基苯乙二醇（MHPG）的水平。
Psychopharmacology (Berl). 1981;74(2):187-90. doi: 10.1007/BF00432691.
2
Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anaesthesia model.在大鼠硫喷妥钠麻醉模型中，典型和非典型抗抑郁药的慢性和急性给药对脑去甲肾上腺素能系统活性的影响
Psychopharmacology (Berl). 1984;84(3):304-9. doi: 10.1007/BF00555203.
3
Behavioural evidence that chronic treatment with the antidepressant desipramine causes reduced functioning of brain noradrenaline systems.

本文引用的文献

1
A method for the assay of conjugated 3,4-dihydroxyphenylglycol, a major noradrenaline metabolite in the rat brain.一种用于测定大鼠脑中主要去甲肾上腺素代谢物——结合型3,4-二羟基苯乙二醇的方法。
J Neurochem. 1976 Nov;27(5):1211-7. doi: 10.1111/j.1471-4159.1976.tb00329.x.
2
Accumulation and disappearance of catecholamines formed from tyrosine-14C in mouse brain; effect of some psychotropic drugs.小鼠脑中由酪氨酸-14C形成的儿茶酚胺的积累与消失；某些精神药物的作用
Eur J Pharmacol. 1968 Nov;4(4):395-403. doi: 10.1016/0014-2999(68)90025-3.
3
Metabolism of normetanephrine-H3 in rat brain--identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite.
行为学证据表明，长期使用抗抑郁药地昔帕明会导致脑去甲肾上腺素系统功能减退。
Psychopharmacology (Berl). 1983;81(1):73-7. doi: 10.1007/BF00439277.
4
Fear-enhanced acoustic startle is not attenuated by acute or chronic imipramine treatment in rats.在大鼠中，急性或慢性丙咪嗪治疗不会减弱恐惧增强的听觉惊吓反应。
Psychopharmacology (Berl). 1985;87(3):278-82. doi: 10.1007/BF00432707.
5
Behavioral, biochemical, and blood pressure responses to alprazolam in healthy subjects: interactions with yohimbine.健康受试者对阿普唑仑的行为、生化及血压反应：与育亨宾的相互作用。
Psychopharmacology (Berl). 1986;88(2):133-40. doi: 10.1007/BF00652229.
6
Studies on rat brain catecholamine synthesis and beta-adrenoceptor number following administration of electroconvulsive shock, desipramine and clenbuterol.电休克、地昔帕明和克伦特罗给药后大鼠脑儿茶酚胺合成及β-肾上腺素能受体数量的研究
J Neural Transm. 1986;65(3-4):245-59. doi: 10.1007/BF01249086.
7
Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats.新生大鼠使用去甲丙咪嗪或齐美利定治疗会导致大脑单胺能系统以及与酒精相关行为的长期改变。
Psychopharmacology (Berl). 1987;91(4):403-9. doi: 10.1007/BF00216004.
8
The effect of acute and chronic desipramine and amitriptyline treatment on rat brain total 3methoxy-4-hydroxyphenylglycol.急性和慢性地昔帕明及阿米替林治疗对大鼠脑总3-甲氧基-4-羟基苯乙二醇的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):207-11. doi: 10.1007/BF00498812.
9
Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities.新型杂环类抗抑郁药坦达明的急性和慢性治疗对生物胺代谢及相关活性的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep;308(3):239-47. doi: 10.1007/BF00501388.
10
The effect of repeated administration of antidepressant drugs on the responsiveness of rats to catecholamine agonists.反复给予抗抑郁药物对大鼠对儿茶酚胺激动剂反应性的影响。
J Neural Transm. 1979;44(3):221-35. doi: 10.1007/BF01253064.
大鼠脑中去甲变肾上腺素 - H3的代谢——鉴定结合型3 - 甲氧基 - 4 - 羟基苯乙二醇为主要代谢产物。
Biochem Pharmacol. 1968 Feb;17(2):247-54. doi: 10.1016/0006-2952(68)90330-4.
4
Changes in norepinephrine turnover in rat brain during chronic administration of imipramine and protriptyline: a possible explanation for the delay in onset of clinical antidepressant effects.慢性给予丙咪嗪和普罗替林期间大鼠脑内去甲肾上腺素周转的变化：临床抗抑郁作用起效延迟的一种可能解释。
Am J Psychiatry. 1971 Feb;127(8):1032-9. doi: 10.1176/ajp.127.8.1032.
5
Norepinephrine turnover and metabolism in rat brain after long-term administration of imipramine.
Science. 1970 May 15;168(3933):867-9. doi: 10.1126/science.168.3933.867.
6
Glycol sulphate ester formation from ( 14 C)noradrenaline in brain and the influence of a COMT inhibitor.大脑中由（14C）去甲肾上腺素形成硫酸甘醇酯以及儿茶酚-O-甲基转移酶抑制剂的影响。
J Neurochem. 1971 Dec;18(12):2461-8. doi: 10.1111/j.1471-4159.1971.tb00203.x.
7
Identification of free and conjugated 3-methoxy-4-hydroxyphenylglycol (MOPEG) in rat brain by gas chromatography and mass fragmentography.采用气相色谱法和质量碎片谱法鉴定大鼠脑中游离和结合的3-甲氧基-4-羟基苯乙二醇（MOPEG）
Anal Biochem. 1973 Oct;55(2):420-31. doi: 10.1016/0003-2697(73)90132-2.
8
Accumulation and metabolism of norepinephrine in rat hypothalamus after exhaustive stress.大鼠经极度应激后下丘脑去甲肾上腺素的蓄积与代谢
J Neurochem. 1973 Sep;21(3):589-601. doi: 10.1111/j.1471-4159.1973.tb06004.x.
9
Increase of noradrenaline metabolism following electrical stimulation of the Locus coeruleus in the rat.大鼠蓝斑电刺激后去甲肾上腺素代谢的增加。
J Neurochem. 1973 Aug;21(2):281-9. doi: 10.1111/j.1471-4159.1973.tb04249.x.
10
Stimulation and destruction of the locus coeruleus: opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex.蓝斑的刺激与损毁：对大鼠大脑皮层中硫酸3-甲氧基-4-羟基苯乙二醇水平的相反影响
Eur J Pharmacol. 1973 Mar;21(3):305-10. doi: 10.1016/0014-2999(73)90131-3.