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压力和药理活性物质对经壁刺激的大鼠胃十二指肠标本中胃蠕动的影响。

The effects of pressure and pharmacologically active substances on gastric peristalsis in a transmurally stimulated rat soomach-duodenum preparation.

作者信息

Armitage A K, Dean A C

出版信息

J Physiol. 1966 Jan;182(1):42-56. doi: 10.1113/jphysiol.1966.sp007807.

DOI:10.1113/jphysiol.1966.sp007807
PMID:5937415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1357454/
Abstract
  1. A rat stomach-duodenum preparation in which pressures in the body and the antrum and flow through the pylorus could be recorded simultaneously has been used to study the effects of pressure and pharmacologically active substances on the peristalsis induced by transmural stimulation.2. Vagal and transmural stimulation produced vigorous peristalsis and episodic flow. Simultaneous stimulation of the peri-arterial nerves abolished peristalsis and relaxed the pylorus.3. After repeated stimulation the preparation lost tone and peristalsis failed. Peristalsis and tone could then be improved by lowering intragastric pressure. Vigorous peristalsis could be restored in an inactive preparation by eserine and more transiently by 5-HT.4. Drugs which increased smooth muscle tone improved peristalsis and, under the conditions used, they reduced flow. Eserine was more active in this respect than acetylcholine or 5-HT.5. Adrenaline and hyoscine abolished peristalsis and caused the stomach and the pylorus to relax.6. The results suggest that the peristaltic activity of the antrum is more important than the tone of the pylorus itself in controlling gastric emptying.
摘要

  1. 一种可同时记录胃体、胃窦压力及通过幽门的血流量的大鼠胃十二指肠标本，已被用于研究压力和药理活性物质对经壁刺激诱发的蠕动的影响。

  2. 迷走神经和经壁刺激可产生强烈蠕动和间歇性血流。同时刺激动脉周围神经可消除蠕动并使幽门松弛。

  3. 反复刺激后，标本失去张力，蠕动消失。此时可通过降低胃内压来改善蠕动和张力。在无活性的标本中，毒扁豆碱可恢复强烈蠕动，5-羟色胺的作用则较短暂。

  4. 增加平滑肌张力的药物可改善蠕动，在所采用的条件下，它们还可减少血流量。在这方面，毒扁豆碱比乙酰胆碱或5-羟色胺更有效。

  5. 肾上腺素和东莨菪碱可消除蠕动，并使胃和幽门松弛。

  6. 结果表明，在控制胃排空方面，胃窦的蠕动活动比幽门本身的张力更为重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/2b50f0f8049c/jphysiol01156-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/f1f942a54d7e/jphysiol01156-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/ae0e5bfe6cad/jphysiol01156-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/5d862e6a8f2a/jphysiol01156-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/46209a9d9afb/jphysiol01156-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/13686972597d/jphysiol01156-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/3689af0a3e46/jphysiol01156-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/ff061384de6b/jphysiol01156-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/e119cc524879/jphysiol01156-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/2b50f0f8049c/jphysiol01156-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/f1f942a54d7e/jphysiol01156-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/ae0e5bfe6cad/jphysiol01156-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/5d862e6a8f2a/jphysiol01156-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/46209a9d9afb/jphysiol01156-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/13686972597d/jphysiol01156-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/3689af0a3e46/jphysiol01156-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/ff061384de6b/jphysiol01156-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/e119cc524879/jphysiol01156-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1a/1357454/2b50f0f8049c/jphysiol01156-0060-a.jpg

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本文引用的文献

1
Function of the pylorus and pyloric antrum in gastric emptying.幽门和幽门窦在胃排空中的作用。
Gut. 1963 Jun;4(2):174-8. doi: 10.1136/gut.4.2.174.
2
The sympathetic innervation of the stomach: III. The interaction of the vagus and sympathetic nerves.胃的交感神经支配：III. 迷走神经与交感神经的相互作用。
J Physiol. 1931 Oct 22;73(2):141-50. doi: 10.1113/jphysiol.1931.sp002802.
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The sympathetic innervation of the stomach: II. The effect of stimulation of the peri-arterial nerves on the stomach and small intestine.胃的交感神经支配：II. 动脉周围神经刺激对胃和小肠的影响。
一只小袋鼠——短尾矮袋鼠（赤褐袋鼠）胃和小肠的肌电活动。
J Physiol. 1983 Sep;342:453-63. doi: 10.1113/jphysiol.1983.sp014862.
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The release of 5-hydroxytryptamine from the rat stomach in vitro.大鼠胃在体外释放5-羟色胺的情况。
J Physiol. 1966 Jan;182(1):57-65. doi: 10.1113/jphysiol.1966.sp007808.
5
Formation of dopamine and noradrenaline in rat vas deferens: comparison with guinea-pig vas deferens.大鼠输精管中多巴胺和去甲肾上腺素的形成：与豚鼠输精管的比较。
Br J Pharmacol. 1975 Sep;55(1):73-8. doi: 10.1111/j.1476-5381.1975.tb07613.x.
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The intrinsic innervation of the human alimentary tract and its relation to function.人类消化道的内在神经支配及其与功能的关系。
Gut. 1975 Jun;16(6):443-53. doi: 10.1136/gut.16.6.443.
J Physiol. 1931 Feb 25;71(2):194-200. doi: 10.1113/jphysiol.1931.sp002725.
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The sympathetic innervation of the stomach: I. The effect on the stomach of stimulation of the thoracic sympathetic trunk.胃的交感神经支配：I. 刺激胸交感干对胃的影响。
J Physiol. 1930 Oct 31;70(3):253-60. doi: 10.1113/jphysiol.1930.sp002693.
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Analysis of he responses of the isolated stomach to electrical stimulation and to drugs.对离体胃对电刺激和药物反应的分析。
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J Physiol. 1960 Feb;150(2):295-305. doi: 10.1113/jphysiol.1960.sp006388.
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J Physiol. 1958 Mar 11;140(3):381-407.
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The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.吗啡及相关物质对同轴刺激的豚鼠回肠收缩和乙酰胆碱释放的作用。
Br J Pharmacol Chemother. 1957 Mar;12(1):119-27. doi: 10.1111/j.1476-5381.1957.tb01373.x.
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10
The release of 5-hydroxytryptamine from the rat stomach in vitro.大鼠胃在体外释放5-羟色胺的情况。
J Physiol. 1966 Jan;182(1):57-65. doi: 10.1113/jphysiol.1966.sp007808.