大鼠胃在体外释放5-羟色胺的情况。
The release of 5-hydroxytryptamine from the rat stomach in vitro.
作者信息
Bennett A, Bucknell A, Dean A C
出版信息
J Physiol. 1966 Jan;182(1):57-65. doi: 10.1113/jphysiol.1966.sp007808.
Abstract
- 5-HT was released into the lumen of the intact isolated rat stomach and into the bath fluid surrounding a preparation of the body and antrum stretched mechanically.2. Release of 5-HT increased when the pressure inside the intact stomach was raised or when the body/antrum preparation was stretched.3. This increased release was not prevented by hexamethonium, atropine, hyoscine or procaine, and was probably due to distortion of cells containing 5-HT.4. During periods of peristalsis induced by transmural stimulation the pharmacological activity of the fluid in the stomach was usually increased owing to a greater release of 5-HT and also to the release of an unidentified substance.5. In reserpine-treated rats, 5-HT was released into the stomach but transmural stimulation did not produce true peristalsis and only rhythmic contractions occurred.6. Peristalsis was seldom reduced by methysergide, and it is concluded that 5-HT is not essential for gastric peristalsis in the rat.
摘要
5-羟色胺（5-HT）被释放到完整的离体大鼠胃腔中，以及被机械拉伸的胃体和胃窦标本周围的浴液中。
当完整胃内压力升高或胃体/胃窦标本被拉伸时，5-HT的释放增加。
六甲铵、阿托品、东莨菪碱或普鲁卡因不能阻止这种释放增加，这可能是由于含5-HT的细胞变形所致。
在经壁刺激诱导的蠕动期间，胃内液体的药理活性通常会增加，这是由于5-HT释放增加以及一种未鉴定物质的释放。
在接受利血平治疗的大鼠中，5-HT被释放到胃中，但经壁刺激不会产生真正的蠕动，仅出现节律性收缩。
胃复安很少能减少蠕动，因此得出结论，5-HT对大鼠的胃蠕动并非必不可少。
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