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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Jones J G, Scotland S M, Dodgson K S

Biochem J. 1966 Jan;98(1):138-41. doi: 10.1042/bj0980138.

A rat-liver supernatant preparation can achieve the biological O-sulphation of l-tyrosylglycine and l-tyrosyl-l-alanine at pH7.0. 2. The optimum concentrations of l-tyrosylglycine and l-tyrosyl-l-alanine in this system are 50mm and 60mm respectively. 3. l-Tyrosylglycine yields two sulphated products, whereas l-tyrosyl-l-alanine yields three sulphated products, when used as acceptor for sulphate in the rat-liver system. 4. With both substrates, one of the sulphated products has been identified as the O-sulphate ester of the corresponding parent peptide.

大鼠肝脏上清液制剂在pH7.0时可实现L-酪氨酰甘氨酸和L-酪氨酰-L-丙氨酸的生物O-硫酸化。2. 该体系中L-酪氨酰甘氨酸和L-酪氨酰-L-丙氨酸的最佳浓度分别为50mM和60mM。3. 在大鼠肝脏体系中，当L-酪氨酰甘氨酸和L-酪氨酰-L-丙氨酸作为硫酸盐受体时，L-酪氨酰甘氨酸产生两种硫酸化产物，而L-酪氨酰-L-丙氨酸产生三种硫酸化产物。4. 对于这两种底物，其中一种硫酸化产物已被鉴定为相应母体肽的O-硫酸酯。

Jones J G, Scotland S M, Dodgson K S

Biochem J. 1966 Jan;98(1):138-41. doi: 10.1042/bj0980138.

A rat-liver supernatant preparation can achieve the biological O-sulphation of l-tyrosylglycine and l-tyrosyl-l-alanine at pH7.0. 2. The optimum concentrations of l-tyrosylglycine and l-tyrosyl-l-alanine in this system are 50mm and 60mm respectively. 3. l-Tyrosylglycine yields two sulphated products, whereas l-tyrosyl-l-alanine yields three sulphated products, when used as acceptor for sulphate in the rat-liver system. 4. With both substrates, one of the sulphated products has been identified as the O-sulphate ester of the corresponding parent peptide.

大鼠肝脏上清液制剂在pH7.0时可实现L-酪氨酰甘氨酸和L-酪氨酰-L-丙氨酸的生物O-硫酸化。2. 该体系中L-酪氨酰甘氨酸和L-酪氨酰-L-丙氨酸的最佳浓度分别为50mM和60mM。3. 在大鼠肝脏体系中，当L-酪氨酰甘氨酸和L-酪氨酰-L-丙氨酸作为硫酸盐受体时，L-酪氨酰甘氨酸产生两种硫酸化产物，而L-酪氨酰-L-丙氨酸产生三种硫酸化产物。4. 对于这两种底物，其中一种硫酸化产物已被鉴定为相应母体肽的O-硫酸酯。