大鼠产生游离L-酪氨酸O-硫酸盐的一种可能途径。
A possible route to the production of free L-tyrosine O-sulphate by the rat.
作者信息
Basford J M, Jones J G, Rose F A, Dodgson K S
出版信息
Biochem J. 1966 Jun;99(3):534-7. doi: 10.1042/bj0990534.
Abstract
- l-Tyrosylglycine O[(35)S]-sulphate is metabolized by the rat to yield the O[(35)S]-sulphate esters of l-tyrosine, p-hydroxyphenylpyruvic acid and p-hydroxyphenylacetic acid. 2. The proportion of the administered peptide which is excreted as l-tyrosine O[(35)S]-sulphate is greater at a higher dose. 3. An enzyme capable of hydrolysing the peptide bond of l-tyrosylglycine O[(35)S]-sulphate to yield l-tyrosine O[(35)S]-sulphate has been detected in rat liver and kidney. 4. The activity of this enzyme is completely inhibited by a large excess of l-tyrosylglycine.
摘要
- L-酪氨酰甘氨酸O-[(35)S]-硫酸盐在大鼠体内代谢，生成L-酪氨酸、对羟基苯丙酮酸和对羟基苯乙酸的O-[(35)S]-硫酸酯。2. 以较高剂量给药时，作为L-酪氨酸O-[(35)S]-硫酸盐排泄的给药肽比例更高。3. 在大鼠肝脏和肾脏中检测到一种能够水解L-酪氨酰甘氨酸O-[(35)S]-硫酸盐的肽键以生成L-酪氨酸O-[(35)S]-硫酸盐的酶。4. 大量过量的L-酪氨酰甘氨酸可完全抑制该酶的活性。
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