大鼠谷胱甘肽S-烷基转移酶的研究。
Studies on glutathione S-alkyltransferase of the rat.
作者信息
Johnson M K
出版信息
Biochem J. 1966 Jan;98(1):44-56. doi: 10.1042/bj0980044.
Abstract
- A rat-liver enzyme catalysing the S-alkylation of glutathione by iodomethane and various other alkyl compounds has been identified and partially purified; its stability, specificity and response to inhibitors and activators and to changes in reaction pH have been studied. 2. The enzyme is distinct from glutathione S-aryltransferase, but both enzymes respond similarly to various inhibitors. 3. A similar enzyme has been found in the kidney and adrenal of rat and in the liver and kidney of numerous species. 4. The identity and the physiological role of the enzyme are discussed.
摘要
- 已鉴定并部分纯化了一种大鼠肝脏酶，该酶可催化谷胱甘肽与碘甲烷及其他各种烷基化合物的S-烷基化反应；研究了其稳定性、特异性以及对抑制剂、激活剂和反应pH变化的响应。2. 该酶与谷胱甘肽S-芳基转移酶不同，但两种酶对各种抑制剂的反应相似。3. 在大鼠的肾脏和肾上腺以及许多物种的肝脏和肾脏中发现了一种类似的酶。4. 讨论了该酶的特性及其生理作用。
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