Wilson D E, Povey S, Harris H
Ann Hum Genet. 1976 Jan;39(3):305-13. doi: 10.1111/j.1469-1809.1976.tb00134.x.
The tissue distribution of the adenylate kinase isozymes in man has been examined using various substrates. The isozymes attributable to the AK1 and AK2 loci were identified, and an additional set of isozymes probably attributable to a third locus was also found. This locus has been provisionally designated AK3. The AK3 isozymes show activity with either GTP + AMP or ITP + AMP but do not show activity with ATP + AMP. They also differ from the AK1 and AK2 isozymes in electrophoretic mobility and from the AK1 isozymes in being resistant to silver inhibition. They are similar in molecular size to the AK1 isozymes whereas the AK2 isozymes are apparently larger. The AK3 isozymes evidently correspond to the enzyme nucleosidetriphosphate-adenylate kinase (2.7.4.10). Somatic cell hybrid studies indicate that the AK3 locus is not syntenic with that of AK2 (chromosome 1). The AK3 locus is however, probably syntenic with the AK1 locus, on chromosome 9. Genetically determined variation of AK3 has not been seen in a survey of about 80 individuals.
利用各种底物对人体中腺苷酸激酶同工酶的组织分布进行了研究。鉴定出了归因于AK1和AK2基因座的同工酶，还发现了另一组可能归因于第三个基因座的同工酶。该基因座已被暂时命名为AK3。AK3同工酶对GTP + AMP或ITP + AMP均有活性，但对ATP + AMP无活性。它们在电泳迁移率方面也与AK1和AK2同工酶不同，在对银抑制的抗性方面与AK1同工酶不同。它们在分子大小上与AK1同工酶相似，而AK2同工酶明显更大。AK3同工酶显然对应于酶核苷三磷酸 - 腺苷酸激酶（2.7.4.10）。体细胞杂交研究表明，AK3基因座与AK2（1号染色体）的基因座不同源。然而，AK3基因座可能与9号染色体上的AK1基因座同源。在对约80个人的调查中未发现AK3的遗传决定变异。
