利用X/9易位和体细胞杂种将人AK1、ACONs和AK3定位到9号染色体上。
Mapping AK1, ACONs, and AK3 to chromosome 9 in man employing and X/9 translocation and somatic cell hybrids.
作者信息
Shows T B, Brown J A
出版信息
Cytogenet Cell Genet. 1977;19(1):26-37. doi: 10.1159/000130791.
The adenylate kinase 1 (AK1), adenylate kinase3 (AK3), and aconitaseS (ACONS) genes have been assigned to chromosome 9 in man by employing an X/9 translocation segregating in man-mouse somatic cell hybrids. Segregation was controlled by taking advantage of the HAT/8-azaguanine selection-counterselection strategy directed at the X-linked HPRT locus. Assignment of AK1 to chromosome 9 has suggested the assignment of the ABO blood-group locus and the nail-patella (Np) locus to 9, since both loci are linked to AK1 by family studies.
通过利用在人-小鼠体细胞杂种中分离的X/9易位，已将腺苷酸激酶1（AK1）、腺苷酸激酶3（AK3）和乌头酸酶S（ACONS）基因定位于人类的9号染色体。通过针对X连锁的次黄嘌呤磷酸核糖转移酶（HPRT）基因座采用HAT/8-氮杂鸟嘌呤选择-反选择策略来控制分离。将AK1定位于9号染色体表明ABO血型基因座和指甲-髌骨（Np）基因座也定位于9号染色体，因为通过家系研究这两个基因座都与AK1连锁。
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