Choulis N H, Abellana-Intaphan L
Pharmazie. 1977 Aug-Sep;32(8-9):518-9.
The preparation and in vivo evaluation of the methadone salts, methadone-o-benzoylbenzoate and methadone-alpha-naphthalenesulfonate, and a number of methadone-naloxone formulations, in the form of three layered slowly eroding tablets, were examined. Male albino rats of the Wistar strain were used as experimental animals and the results indicated that a prolongation of the resistance to pain threshold was attained, though severe side-effects were observed. A number of animals died during these experimental procedures.
对美沙酮盐、美沙酮邻苯甲酰苯甲酸酯和美沙酮α-萘磺酸盐以及多种美沙酮-纳洛酮制剂（以三层缓释片形式）进行了制备及体内评估。使用Wistar品系的雄性白化大鼠作为实验动物，结果表明，尽管观察到严重的副作用，但对疼痛阈值的抵抗力有所延长。在这些实验过程中有多只动物死亡。
