黄酮类代谢研究。豚鼠体内黄酮的代谢。
Studies on flavonoid metabolism. Metabolism of flavone in the guinea pig.
作者信息
Das N P, Griffiths L A
出版信息
Biochem J. 1966 Feb;98(2):488-92. doi: 10.1042/bj0980488.
Abstract
- The metabolism of flavone has been studied in the guinea pig; after administration of the compound either orally or intraperitoneally, 4'-hydroxyflavone is excreted in the urine. 2. Small amounts of 3',4'-dihydroxyflavone were also detected in the urine after oral administration of flavone. 3. Hydroxyflavone formation is not suppressed by administering high doses of the antibacterial compounds aureomycin and phthaloylsulphathiazole. 4. Although salicylic acid appeared in trace quantities in the urine after administration of flavone, no other aromatic acid metabolites of flavone were detected.
摘要
- 已在豚鼠身上研究了黄酮的代谢；经口服或腹腔注射该化合物后，4'-羟基黄酮会随尿液排出。2. 口服黄酮后，尿液中也检测到少量的3',4'-二羟基黄酮。3. 高剂量的抗菌化合物金霉素和酞酰磺胺噻唑的给药不会抑制羟基黄酮的形成。4. 虽然黄酮给药后尿液中出现了微量水杨酸，但未检测到黄酮的其他芳香酸代谢物。
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