黄酮类化合物代谢研究。豚鼠体内（+）-儿茶素的代谢
Studies on flavonoid metabolism. Metabolism of (+)-catechin in the guinea pig.
作者信息
Das N P, Griffiths L A
出版信息
Biochem J. 1968 Dec;110(3):449-56. doi: 10.1042/bj1100449.
Abstract
- Administration of (+)-catechin to the guinea pig gives rise to a number of phenolic acids and lactones, which have been identified by chromatographic and spectrophotometric methods. The major phenolic acid metabolite is m-hydroxybenzoic acid and the major lactone metabolite is delta-(3-hydroxyphenyl)-gamma-valerolactone. 2. The phenolic acid and lactone metabolites are excreted in both free and conjugated forms, including their glucuronides and to a lesser degree their ethereal sulphates. 3. Administration of certain of the metabolites isolated has permitted certain sequential relationships of these intermediates to be established. 4. Degradation of (+)-catechin in the guinea pig is effected at least in part by the gut microflora and is suppressed by aureomycin plus phthaloyl-sulphathiazole.
摘要
- 给豚鼠施用（+）-儿茶素会产生多种酚酸和内酯，这些已通过色谱和分光光度法鉴定出来。主要的酚酸代谢物是间羟基苯甲酸，主要的内酯代谢物是δ-（3-羟基苯基）-γ-戊内酯。2. 酚酸和内酯代谢物以游离和结合形式排泄，包括它们的葡糖醛酸苷，以及程度较低的硫酸酯。3. 施用某些分离出的代谢物有助于确定这些中间体之间的某些顺序关系。4. 豚鼠体内（+）-儿茶素的降解至少部分是由肠道微生物群实现的，并且会被金霉素加邻苯二甲酰磺胺噻唑抑制。
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