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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Biochem J. 1966 Feb;98(2):636-40. doi: 10.1042/bj0980636.

In the rat cerebral cortex net DNA synthesis ceases when the animal has reached about 25g. body weight (18 days of age). There is then little further change in the DNA content per cortex. 2. Nuclear and transfer RNA follow a similar pattern to DNA. 3. Microsomal and ribosomal RNA content increases up to 25g. body weight but then declines. The decrease in ribosomal and microsomal RNA content is associated with a change in RNA base composition. 4. Incorporation of [(14)C]orotic acid into nuclear RNA proceeds at a similar rate in 4-day-old and adult animals. However, there is a lag period of about 60min. in the young animals during which incorporation into the ribosome fractions proceeds slowly. In the adult animals the lag period is not seen.

在大鼠大脑皮层中，当动物体重达到约25克（18日龄）时，净DNA合成停止。此后，每个皮层的DNA含量几乎没有进一步变化。2. 核RNA和转运RNA遵循与DNA相似的模式。3. 微粒体和核糖体RNA含量在体重达到25克之前增加，但随后下降。核糖体和微粒体RNA含量的下降与RNA碱基组成的变化有关。4. 在4日龄和成年动物中，[（14）C]乳清酸掺入核RNA的速率相似。然而，幼龄动物中有一个约60分钟的延迟期，在此期间掺入核糖体部分的过程进行缓慢。在成年动物中则没有观察到延迟期。

Biochem J. 1966 Feb;98(2):636-40. doi: 10.1042/bj0980636.

In the rat cerebral cortex net DNA synthesis ceases when the animal has reached about 25g. body weight (18 days of age). There is then little further change in the DNA content per cortex. 2. Nuclear and transfer RNA follow a similar pattern to DNA. 3. Microsomal and ribosomal RNA content increases up to 25g. body weight but then declines. The decrease in ribosomal and microsomal RNA content is associated with a change in RNA base composition. 4. Incorporation of [(14)C]orotic acid into nuclear RNA proceeds at a similar rate in 4-day-old and adult animals. However, there is a lag period of about 60min. in the young animals during which incorporation into the ribosome fractions proceeds slowly. In the adult animals the lag period is not seen.

在大鼠大脑皮层中，当动物体重达到约25克（18日龄）时，净DNA合成停止。此后，每个皮层的DNA含量几乎没有进一步变化。2. 核RNA和转运RNA遵循与DNA相似的模式。3. 微粒体和核糖体RNA含量在体重达到25克之前增加，但随后下降。核糖体和微粒体RNA含量的下降与RNA碱基组成的变化有关。4. 在4日龄和成年动物中，[（14）C]乳清酸掺入核RNA的速率相似。然而，幼龄动物中有一个约60分钟的延迟期，在此期间掺入核糖体部分的过程进行缓慢。在成年动物中则没有观察到延迟期。