牛胃黏膜微粒体对血栓素B2和前列腺素的合成

Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes.

作者信息

Ali M, Zamecnik J, Cerskus A L, Stoessl A J, Barnett W H, McDonald J W

出版信息

Prostaglandins. 1977 Nov;14(5):819-27. doi: 10.1016/0090-6980(77)90299-4.

Abstract

Bovine gastric mucosal microsomes synthesize prostaglandins from arachidonic acid but thromboxane B2 is the principal product. Thromboxane B2 synthesis occurs at an appreciable rate from endogenous precursor but more rapidly with added arachidonate. Nonsteroidal antiinflammatory drugs inhibited synthesis of prostaglandins and thromboxanes with the following decreasing order of potency: indomethacin, fenoprofen, acetylsalicylic acid, phenylbutazone, sulfinpyrazone, and acetaminophen.

摘要

牛胃黏膜微粒体可从花生四烯酸合成前列腺素，但血栓素B2是主要产物。血栓素B2可由内源性前体以可观的速率合成，但添加花生四烯酸后合成速度更快。非甾体抗炎药抑制前列腺素和血栓素的合成，其效力递减顺序如下：吲哚美辛、非诺洛芬、乙酰水杨酸、保泰松、磺吡酮和对乙酰氨基酚。