Ross R, Klebanoff S J
J Exp Med. 1966 Oct 1;124(4):653-60. doi: 10.1084/jem.124.4.653.
This study has presented the fine structure changes in the eosinophilic leukocyte in the rat uterus during the estrous cycle. Eosinophils were seen to emigrate into the uterine connective tissues from the blood stream. Just prior to, during estrus, and 1 day postestrus, eosinophilic leukocytes underwent lysis releasing their contents into the extracellular spaces and both whole eosinophils and individual granules from lysed cells were ingested by resident macrophages. No phagocytic activity by eosinophils was observed. The possible relationship of the turnover of eosinophils to the profound morphologic and chemical changes in the uterus during the estrous cycle was discussed.
本研究呈现了大鼠子宫在发情周期中嗜酸性白细胞的精细结构变化。可见嗜酸性粒细胞从血流迁移至子宫结缔组织。在发情前期、发情期及发情后1天，嗜酸性白细胞发生溶解，将其内容物释放到细胞外间隙，完整的嗜酸性粒细胞和溶解细胞中的单个颗粒均被常驻巨噬细胞吞噬。未观察到嗜酸性粒细胞的吞噬活性。讨论了嗜酸性粒细胞更新与发情周期中子宫深刻的形态学和化学变化之间的可能关系。
