Greendyke R M, Banzhaf J C
Transfusion. 1977 Nov-Dec;17(6):621-4. doi: 10.1046/j.1537-2995.1977.17678075661.x.
The occurrence of the Wr a antigen on the red blood cells of 5,000 primarily Caucasian New York State blood donors was shown to be 1:1,000. Anti-Wr a was detected in sera from random blood donors with a frequency of 1:56 and with progressively increasing frequency in postpartum women, patients undergoing open-heart surgery, hemodialysis subjects, and random persons with other alloantibodies. Anti-Wr a was found in one fourth of sera from patients with positive direct antiglobulin tests, including 12 of 23 in whom the positive test was associated with alphamethyldopa treatment.
对5000名主要为白种人的纽约州献血者的红细胞进行检测，结果显示Wr a抗原的出现频率为1:1000。在随机献血者血清中检测到抗Wr a的频率为1:56，而在产后妇女、接受心脏直视手术的患者、血液透析患者以及有其他同种抗体的随机人群中，其频率逐渐增加。在直接抗球蛋白试验呈阳性的患者血清中，有四分之一检测到抗Wr a，其中23例中有12例阳性试验与α -甲基多巴治疗有关。
