Ermolaev M V, Semenova M V
Vopr Med Khim. 1977 Sep-Oct;23(5):635-8.
Metabolism of serotonin was studied in duodenum of rabbits in acute kidney ischemia (from 15 min to 1 hr). Estimations of serotonin and 5-hydroxy indolacetic acid content and the activities of 5-hydroxytryptophane decarboxylase (5-HTD) and monoamine oxidase (MAO) using serotonin as a substrate were carried out. A complicated phase dynamics in the intestine of main patterns of serotonin metabolism was observed in acute kidney ischemia. Within the ischemic period content of serotonin and the MAO activity correlated with the activity of 5-HTD in the duodenal tissue. The alterations in the activity of MAO from intestine suggest that this enzyme was especially important in the serotonin metabolic conversions studied.
在急性肾缺血（15分钟至1小时）的家兔十二指肠中研究了血清素的代谢。对血清素和5-羟吲哚乙酸含量进行了测定，并以血清素为底物对5-羟色氨酸脱羧酶（5-HTD）和单胺氧化酶（MAO）的活性进行了测定。在急性肾缺血时，观察到肠道中血清素代谢主要模式的复杂阶段动态变化。在缺血期，血清素含量和MAO活性与十二指肠组织中5-HTD的活性相关。肠道中MAO活性的改变表明，该酶在所研究的血清素代谢转化中尤为重要。
