Valdina E A, Puchkov Iu G
Vopr Onkol. 1977;23(11):23-9.
Under study was the kinetics of morphological changes of high-differentiated carcinomas of the thyroid after repeat operative interventions, the interval between those was 2--15 years. It is suggested that during the development of high differentiated thyroid tumors the morphological structure of the tumor is remained and shows no tendency to transformation into anaplastic forms. Tumors showing both papillary and anaplastic structures (papillary polymorphous cancers) are considered to be the result of irregular tumor progression under which separate zones of neoplastic cells proved to be in different stages of differentiation.
本研究关注的是甲状腺高分化癌在重复手术干预后的形态学变化动力学,两次手术间隔时间为2至15年。研究表明,在高分化甲状腺肿瘤的发展过程中,肿瘤的形态结构保持不变,且无向间变性形式转变的趋势。同时具有乳头状和间变结构的肿瘤(乳头状多形性癌)被认为是肿瘤不规则进展的结果,在此过程中,肿瘤细胞的不同区域处于不同的分化阶段。