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The metabolism of 5-fluorocytosine-2-14-C and of cytosine-14-C in the rat and the disposition of 5-fluorocytosine-2-14-C in man.

作者信息

Koechlin B A, Rubio F, Palmer S, Gabriel T, Duschinsky R

出版信息

Biochem Pharmacol. 1966 Apr;15(4):435-46. doi: 10.1016/0006-2952(66)90254-1.

DOI:10.1016/0006-2952(66)90254-1
PMID:5955812
Abstract
摘要

相似文献

1
The metabolism of 5-fluorocytosine-2-14-C and of cytosine-14-C in the rat and the disposition of 5-fluorocytosine-2-14-C in man.5-氟胞嘧啶-2-¹⁴C和胞嘧啶-¹⁴C在大鼠体内的代谢以及5-氟胞嘧啶-2-¹⁴C在人体内的分布。
Biochem Pharmacol. 1966 Apr;15(4):435-46. doi: 10.1016/0006-2952(66)90254-1.
2
The kinetics of 5-fluorocytosine elimination in man.
Aust N Z J Med. 1972 May;2(2):153-8. doi: 10.1111/j.1445-5994.1972.tb03925.x.
3
Catabolism of 14C-thiazole-labeled oxythiamine and its effects on thiamine catabolism in the rat.
J Nutr. 1968 Oct;96(2):206-14. doi: 10.1093/jn/96.2.206.
4
4-Methylthiazole-5-acetic acid--a urinary metabolite of thiamine.
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5
Fluorometric measurement of 5-fluorocytosine in biological fluids.
J Pharm Sci. 1973 May;62(5):828-9. doi: 10.1002/jps.2600620531.
6
Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect.基于胞嘧啶脱氨酶/5-氟胞嘧啶的肝癌疫苗接种：远处旁观者效应的证据。
J Natl Cancer Inst. 1999 Dec 1;91(23):2014-9. doi: 10.1093/jnci/91.23.2014.
7
5-fluorocytosine and urinary candidiasis.5-氟胞嘧啶与尿念珠菌病
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8
Adenovirus mediated cytosine deaminase gene transduction and 5-fluorocytosine therapy sensitizes mouse prostate cancer cells to irradiation.腺病毒介导的胞嘧啶脱氨酶基因转导及5-氟胞嘧啶治疗使小鼠前列腺癌细胞对辐射敏感。
J Urol. 2000 Dec;164(6):2173-7.
9
5-fluorocytosine: an oral antifungal compound. A report on clinical and laboratory experience.
Ann Intern Med. 1972 Jan;76(1):15-22. doi: 10.7326/0003-4819-76-1-15.
10
Biological activity and excreation of the riboflavin analogues, 6,7-dimethyl-9-(omega-carboxyalkyl)-isoalloxazines in rats.
J Nutr. 1969 Mar;97(3):307-10. doi: 10.1093/jn/97.3.307.

引用本文的文献

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Aspergillus Niger thermostable Cytosine deaminase-dextran conjugates with enhanced structure stability, proteolytic resistance, and Antiproliferative activity.黑曲霉耐热胞嘧啶脱氨酶-葡聚糖缀合物具有增强的结构稳定性、抗蛋白水解性和抗增殖活性。
BMC Microbiol. 2023 Jan 10;23(1):9. doi: 10.1186/s12866-023-02754-8.
2
Improved cytotoxic effects of Salmonella-producing cytosine deaminase in tumour cells.产胞嘧啶脱氨酶的沙门氏菌对肿瘤细胞的细胞毒性作用增强。
Microb Biotechnol. 2015 Jan;8(1):169-76. doi: 10.1111/1751-7915.12153. Epub 2014 Sep 16.
3
Inhibitory effect of pulmonary carcinoma by adenovirus-mediated CD/UPRT gene.
腺病毒介导的CD/UPRT基因对肺癌的抑制作用
J Huazhong Univ Sci Technolog Med Sci. 2006;26(5):591-3. doi: 10.1007/s11596-006-0529-0.
4
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.用胞嘧啶脱氨酶基因转导的人结肠直肠肿瘤细胞中5-氟胞嘧啶向5-氟尿嘧啶的代谢：仅一小部分肿瘤细胞表达胞嘧啶脱氨酶时即有显著抗肿瘤作用。
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8302-6. doi: 10.1073/pnas.91.17.8302.
5
Peritoneal clearance of amphotericin B and 5-fluorocytosine.两性霉素B和5-氟胞嘧啶的腹膜清除率。
West J Med. 1980 Aug;133(2):157-60.
6
5-fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol: potential for improving the therapeutic index of 5-fluorocytosine.别嘌呤醇存在下致病真菌对5-氟胞嘧啶的敏感性：提高5-氟胞嘧啶治疗指数的潜力
Antimicrob Agents Chemother. 1983 Sep;24(3):448-9. doi: 10.1128/AAC.24.3.448.
7
Improved procedure for determination of flucytosine in human blood plasma by high-pressure liquid chromatography.高压液相色谱法测定人血浆中氟胞嘧啶的改进方法。
Antimicrob Agents Chemother. 1984 Sep;26(3):303-5. doi: 10.1128/AAC.26.3.303.
8
Candida esophagitis.念珠菌性食管炎
Dig Dis Sci. 1983 Apr;28(4):365-70. doi: 10.1007/BF01324956.
9
Clinical pharmacokinetics of systemic antifungal drugs.全身性抗真菌药物的临床药代动力学。
Clin Pharmacokinet. 1983 Jan-Feb;8(1):17-42. doi: 10.2165/00003088-198308010-00002.
10
Chemotherapy of experimental endogenous Candida albicans endophthalmitis.实验性内源性白色念珠菌眼内炎的化疗
Trans Am Ophthalmol Soc. 1980;78:846-95.