Rossi G, Campodonico M, Hernandez G
Rev Med Chil. 1989 Aug;117(8):884-8.
We monitored plasma levels of gentamycin in 28 patients being treated for different infectious processes. The mean age was 53.7 years. Drug dose and administration was determined by the treating physician, without knowledge of plasma levels. Peak and through levels were measured by RIA after the third and 7th dose. No patient had adequate therapeutic levels throughout the treatment period and 6 were therapeutic failures. Patients with renal insufficiency frequently had toxic plasma levels. Monitoring gentamycin plasma levels is recommended for all patients receiving the drug, especially those with renal insufficiency or therapeutic failure.
我们监测了28例因不同感染性疾病接受治疗的患者的庆大霉素血浆水平。平均年龄为53.7岁。药物剂量和给药方式由主治医生确定，且医生不知道血浆水平。在第三剂和第七剂给药后，通过放射免疫分析法测定峰值和谷值水平。在整个治疗期间，没有患者达到足够的治疗水平，6例治疗失败。肾功能不全的患者经常出现血浆中毒水平。建议对所有接受该药物治疗的患者进行庆大霉素血浆水平监测，尤其是那些肾功能不全或治疗失败的患者。
