Alsabti E A, Safo M
Jpn J Exp Med. 1978 Aug;48(4):283-5.
Radial immunodiffusion assay was used to measure fetal hemoglobin (HbF) concentrations in 312 patients with various malignancies. In 305 of these, alpha-fetoprotein (AFP) was measured by radioimmunoassay. The concentration of HbF exceeded 3 SDs above the normal mean in 68 of 312 patients, most notably in patients with leukemia, multiple myeloma, lymphoma, bladder carcinoma and testicular tumors. HbF was correlated with total hemoglobin concentration and with serum AFP concentration in hepatoma and bladder carcinoma.
采用放射免疫扩散法测定了312例各种恶性肿瘤患者的胎儿血红蛋白(HbF)浓度。其中305例患者采用放射免疫分析法测定了甲胎蛋白(AFP)。312例患者中有68例的HbF浓度超过正常均值3个标准差以上,最显著的是白血病、多发性骨髓瘤、淋巴瘤、膀胱癌和睾丸肿瘤患者。在肝癌和膀胱癌中,HbF与总血红蛋白浓度及血清AFP浓度相关。