Whittle H C, Greenwood B M, Bidwell D E, Bartlett A, Voller A
Am J Trop Med Hyg. 1977 Nov;26(6 Pt 1):1129-34. doi: 10.4269/ajtmh.1977.26.1129.
Serum and cerebrospinal fluid (CSF) IgM were measured in 182 patients at various stages of Gambian sleeping sickness and correlated with antibody levels measured by enzyme-linked immunosorbent assay (ELISA). Each of these tests in serum gave a 30% false negative result, but when both were used this fell to 12%. Measurements of IgM in CSF were raised in 87% of patients with advanced disease and in none of the early cases. The IgM levels fell slowly to normal by 12 months after treatment. A high level at this time, or a rise after treatment, was helpful in diagnosing relapsed patients. Antibody levels in CSF were of no use in diagnosis or prognosis, and were raised in many controls.
对182例处于冈比亚昏睡病不同阶段的患者进行了血清和脑脊液（CSF）IgM检测，并将其与通过酶联免疫吸附测定（ELISA）测得的抗体水平进行关联。血清中的每项此类检测均有30%的假阴性结果，但两项检测同时使用时，该比例降至12%。晚期疾病患者中87%的脑脊液IgM测量值升高，早期病例中无一升高。治疗后12个月时，IgM水平缓慢降至正常。此时的高水平或治疗后的升高有助于诊断复发患者。脑脊液中的抗体水平对诊断或预后无用，且在许多对照中也升高。
