高压氧对大鼠肝脏线粒体细胞色素稳态的影响。
Effect of high pressure oxygen on the steady state of cytochromes in rat-liver mitochondria.
作者信息
Jamieson D, Chance B
出版信息
Biochem J. 1966 Jul;100(1):254-62. doi: 10.1042/bj1000254.
Abstract
- The split-beam spectrophotometer was used to monitor changes in the steady state of cytochrome c and cytochromes a+a(3) during pressurization in pure oxygen. 2. High-pressure oxygen was found to cause oxidation of cytochrome c in rat-liver mitochondria, and of cytochromes a+a(3) at low pH. 3. No difference in these effects was found when various substrates were metabolized. 4. Lowering of pH markedly potentiated the high-pressure effect on the cytochromes. 5. Increased temperature and pressure hastened the reaction to high-pressure oxygen. 6. The oxidation of the cytochromes occurs on the substrate side of cytochrome c, probably at the dehydrogenase level, and the time-course of the reaction is compared with effects of oxygen toxicity in vivo.
摘要
- 采用分束分光光度计监测纯氧加压过程中细胞色素c和细胞色素a+a₃稳态的变化。2. 发现高压氧可导致大鼠肝脏线粒体中细胞色素c以及低pH值下细胞色素a+a₃的氧化。3. 当代谢各种底物时，未发现这些效应存在差异。4. pH值降低显著增强了高压对细胞色素的作用。5. 温度和压力升高加速了对高压氧的反应。6. 细胞色素的氧化发生在细胞色素c的底物侧，可能在脱氢酶水平，并且将反应的时间进程与体内氧毒性的效应进行了比较。
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