[过氧化物化合物的形成及其在多烯抗生素左菌素和霉菌肝菌素失活中的作用]

[Formation of peroxide compounds and their role in the inactivation of polyene antibiotics levorin and mycoheptin].

作者信息

Kasaikina O T, Podkovyrina L G, Severinets L Ia, Gagarina A B

出版信息

Antibiotiki. 1977 Nov;22(11):977-81.

Abstract

The kinetics of peroxide formation in the process of levorin and mycoheptin oxidation at a temperature of 57 degrees C was studied. It was shown that the peroxide compounds actively participated in the processes of levorin and mycoheptin inactivation as intermediate products of their transformation. Addition of the peroxides increased the rate of the antibiotic degradation even if there was no oxygen and subsequently decreased the periods of their storage. Conditions for the use of the iodometric method for determination of the peroxides in the poyenic compounds are discussed.

摘要

研究了在57摄氏度下左菌素和霉菌肝磷脂氧化过程中过氧化物形成的动力学。结果表明，过氧化物化合物作为其转化的中间产物，积极参与左菌素和霉菌肝磷脂的失活过程。即使没有氧气，过氧化物的添加也会增加抗生素的降解速率，随后缩短其储存期。讨论了用碘量法测定多烯化合物中过氧化物的条件。

相似文献

1

[Formation of peroxide compounds and their role in the inactivation of polyene antibiotics levorin and mycoheptin].[过氧化物化合物的形成及其在多烯抗生素左菌素和霉菌肝菌素失活中的作用]

Antibiotiki. 1977 Nov;22(11):977-81.

2

[Inactivation mechanism of polyene antibiotics. The change in the functional component of levorin during inactivation].[多烯抗生素的失活机制。左菌素失活过程中功能成分的变化]

Antibiotiki. 1980 Aug;25(8):566-71.

3

[Mechanism of polyene antibiotic inactivation. Possible ways for levorin stabilization].

Antibiotiki. 1982 Aug;27(8):585-8.

4

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Antibiotiki. 1982 Apr;27(4):269-75.

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Antibiotiki. 1982;27(7):496-501.

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7

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Biophys J. 1994 Jul;67(1):143-52. doi: 10.1016/S0006-3495(94)80463-1.

10

[Mathematical model of zone formation taking into account the inactivation of polyene antibiotics diffusing into an inoculated gel].

Antibiotiki. 1981 Sep;26(9):676-80.

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