Bronov L V, Kroshilova T M, Kolosova O M, Krunchak V G, Komarov E V
Antibiotiki. 1982 Jun;27(6):430-4.
Changes in the acid-base characteristics of levorin during its inactivation are discussed. It is shown that with a decrease in the biological activity a change in the basic characteristics of the levorin amino sugar moiety takes place. The kinetic studies with model compounds, i. e. octaenic alcohol and glucosamine showed that the processes of their oxidation were interrelated. Oxidation of the amino sugar played the role of an inducing factor in oxidation of the polyenic chromophore and in addition impaired correlation between the extinction specific coefficient of levorin and its biological activity.
讨论了左菌素失活过程中酸碱特性的变化。结果表明，随着生物活性的降低，左菌素氨基糖部分的碱性特征发生了变化。用模型化合物（即辛烯醇和葡萄糖胺）进行的动力学研究表明，它们的氧化过程是相互关联的。氨基糖的氧化在多烯发色团的氧化中起诱导因子的作用，此外还破坏了左菌素比消光系数与其生物活性之间的相关性。
