影响一系列烷基甲基膦酰基 - 乙酰胆碱酯酶“老化”速率的因素。
Factors influencing the rate of "aging" of a series of alkyl methylphosphonyl-acetylcholinesterases.
作者信息
Berry W K, Davies D R
出版信息
Biochem J. 1966 Aug;100(2):572-6. doi: 10.1042/bj1000572.
Abstract
- The progressive development of resistance to reactivation by an oxime (;aging') shown by a series of alkyl methylphosphonyl-acetylcholinesterases is slow when the alkyl group is a primary alcohol, whether or not the carbon chain is branched, but is much more rapid if the alkyl group is a secondary or cyclic alcohol. 2. Aging is accelerated by increase of temperature or decrease of pH. 3. Aging is inhibited by the quaternary amine N-methylpyridinium iodide. 4. The results are discussed in relation to the role played by aging in the therapy of poisoning by organophosphorus compounds.
摘要
- 一系列烷基甲基磷酰基-乙酰胆碱酯酶对肟（“老化”）重新激活产生抗性的逐步发展，当烷基为伯醇时缓慢，无论碳链是否分支，但如果烷基为仲醇或环醇则快得多。2. 温度升高或pH降低会加速老化。3. 季铵盐碘化N-甲基吡啶鎓可抑制老化。4. 结合老化在有机磷化合物中毒治疗中所起的作用对结果进行了讨论。
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