抑制哺乳新生大鼠脂肪酸氧化的作用
The effects of inhibition of fatty acid oxidation in suckling newborn rats.
作者信息
Pégorier J P, Ferré P, Girard J
出版信息
Biochem J. 1977 Sep 15;166(3):631-4. doi: 10.1042/bj1660631.
Abstract
Inhibition of fatty acid oxidation with pent-4-enoate in suckling newborn rats caused a fall in blood [glucose] and blood [ketone bodies] and inhibition of gluconeogenesis from lactate. Glucose utilization was not increased in newborn rats injected with pent-4-enoate. Active fatty acid oxidation appears to be essential to support gluconeogenesis and to maintain normal blood [glucose] in suckling newborn rats.
摘要
用4-戊烯酸抑制乳鼠的脂肪酸氧化会导致血糖浓度和血酮体浓度下降，并抑制由乳酸生成葡萄糖的糖异生过程。给新生大鼠注射4-戊烯酸后，葡萄糖利用率并未增加。活跃的脂肪酸氧化对于支持糖异生和维持乳鼠正常血糖水平似乎至关重要。
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