Beral V, Ramcharan S, Faris R
Br J Cancer. 1977 Dec;36(6):804-9. doi: 10.1038/bjc.1977.265.
Women who had used oral contraceptives, particularly long-term users, were found to have higher rates of malignant melanoma and of a past history of skin cancer than those who had never used oral contraceptives. This excess was confined to lesions of the lower limb. The association between oral contraceptive use and melanoma was noted in 3 separate sets of data, although it was statistically significant only in one. The possibility that this relationship is indirect because, for example, oral contraceptive users are more likely than never-users to be exposed to sunlight and thus to develop malignant melanoma, cannot be excluded.
研究发现，使用口服避孕药的女性，尤其是长期使用者，患恶性黑色素瘤的几率以及有皮肤癌病史的比例均高于从未使用过口服避孕药的女性。这种差异仅限于下肢病变。在3组独立数据中均发现了口服避孕药使用与黑色素瘤之间的关联，不过只有一组数据具有统计学意义。不能排除这种关系是间接的可能性，例如，口服避孕药使用者比从未使用者更易暴露于阳光下，从而患上恶性黑色素瘤。
