Wyborney V J, Walch H, Loeffler A B, Wiita R M
Calif Med. 1966 Oct;105(4):265-70.
Three cases of histoplasmosis, a disease seldom reported in California, were diagnosed clinically by the authors in San Diego County. It is probable that there is a higher incidence of this disease in California than is at present recognized. Travel history, histoplasmin skin testing and serologic studies for mycotic infection are important in the diagnosis. Cultures of secretions and biopsy material are of great value if positive; but negative cultures (at least in non-endemic areas) do not rule out the disease. Travel and migration to and from endemic areas present opportunities for this disease to constitute a diagnostic problem far from the geographic area in which the disease was acquired.Although usually benign, histoplasmosis may be severe in the acute state, may disseminate or may be chronically active and progressive. Amphotericin B is the only effective chemotherapeutic agent and it is usually reserved for these forms of the disease.
作者在圣地亚哥县临床诊断出3例组织胞浆菌病，这种疾病在加利福尼亚州鲜有报道。加利福尼亚州该疾病的发病率可能比目前公认的要高。旅行史、组织胞浆菌素皮肤试验以及真菌性感染的血清学研究对诊断很重要。分泌物和活检材料培养若呈阳性则具有很大价值；但培养结果为阴性（至少在非流行地区）并不能排除该病。往返于流行地区的旅行和迁徙使得该病在远离患病地区的地方构成诊断难题。组织胞浆菌病虽然通常为良性，但在急性期可能很严重，可能会播散，也可能呈慢性活动和进行性。两性霉素B是唯一有效的化疗药物，通常仅用于治疗该病的这些类型。
