Cresteil T
Can J Physiol Pharmacol. 1977 Dec;55(6):1242-5. doi: 10.1139/y77-169.
An adenyl cyclase activity was measurable in the brown adipose tissue of fetal rat, and could be stimulated in vitro by noradrenaline during the last 3 days of fetal life. The stimulating effect of noradrenaline was maximal at birth and decreased during the first days of extrauterine life. Ingestion by mother of a high lipid diet modified the developmental pattern of fetal adenyl cyclase. The linoleic acid content of mother's diet had no effect on the noradrenaline- or fluoride-stimulated specific activities except on the day 22 of gestation. Relative noradrenaline-stimulated activity, expressed as a fraction of the maximal activity, was significantly increased in fetuses and 1-day-old newborns from mothers fed a high linoleic acid diet, but no effect was observed in suckling newborns.
在胎鼠的棕色脂肪组织中可检测到腺苷酸环化酶活性，在胎儿期的最后3天，去甲肾上腺素可在体外刺激该活性。去甲肾上腺素的刺激作用在出生时最大，在出生后的头几天会下降。母体摄入高脂饮食会改变胎儿腺苷酸环化酶的发育模式。母体饮食中的亚油酸含量对去甲肾上腺素或氟化物刺激的比活性没有影响，除非在妊娠第22天。以最大活性的分数表示的相对去甲肾上腺素刺激活性，在喂食高亚油酸饮食的母亲所生的胎儿和1日龄新生儿中显著增加，但在哺乳新生儿中未观察到影响。
