Quirion R, Rioux F, Regoli D
Can J Physiol Pharmacol. 1978 Jun;56(3):509-11. doi: 10.1139/y78-076.
Aortic strips removed from spontaneously hypertensive (SH) rats and preincubated with arachidonic acid (1.0 X 10(-5) g/ml) for 15 min produced two times more prostaglandin (PG) like material than aortae unexposed to the precursor of PG biosynthesis. The stimulating effect of arachidonic acid was largely inhibited by indomethacin (1.0 X 10(-5) g/ml). Also, the release of PG-like material by aortic strips derived from SH rats treated with an intravenous injection of indomethacin (10 mg/kg) was inhibited by 74% compared with the control tissues. These results raised the possibility that the in vivo conversion of arachidonic acid by large arteries of SH rats may contribute to the hypotensive effect of this PG precursor in SH rats.
从自发性高血压（SH）大鼠身上取下的主动脉条，与花生四烯酸（1.0×10⁻⁵克/毫升）预孵育15分钟后，产生的前列腺素（PG）样物质比未接触PG生物合成前体的主动脉多两倍。花生四烯酸的刺激作用在很大程度上被消炎痛（1.0×10⁻⁵克/毫升）抑制。此外，与对照组织相比，静脉注射消炎痛（10毫克/千克）处理的SH大鼠主动脉条释放的PG样物质被抑制了74%。这些结果增加了一种可能性，即SH大鼠大动脉中花生四烯酸的体内转化可能有助于这种PG前体对SH大鼠的降压作用。
