Hemmeloff Andersen K E
Clin Nephrol. 1977 Dec;8(6):510-3.
Twenty-five uremic patients on chronic hemodialysis were followed over a period of 9 months with regard to hemoglobin, mean corpuscular volume and folate concentration in serum and erythrocytes. The daily dietary intake of folic acid was estimated at 80-90 microgram, and no folic acid supplements were given. None of the patients developed macrocytic anemia. At the end of the period all patients had a normal erythrocyte folate content. Serum folate was normal in 17 and below normal in 8 patients. These 8 patients were in a negative folate balance at the time of investigation. In 7 patients dialyzed with a RP VI dialyzer the maximum loss of folic acid was 75 microgram/dialysis, and in 6 patients on chronic intermittent peritoneal dialysis the maximum loss was 13 microgram/dialysis. Thus there is no need for oral folic acid supplementation in uremic patients on chronic dialysis provided that daily dietary intake of folic acid is adequate.
对25名接受慢性血液透析的尿毒症患者进行了为期9个月的随访，观察其血红蛋白、平均红细胞体积以及血清和红细胞中的叶酸浓度。估计每日膳食叶酸摄入量为80 - 90微克，且未给予叶酸补充剂。所有患者均未发生巨幼细胞贫血。在该阶段结束时，所有患者的红细胞叶酸含量均正常。17名患者的血清叶酸正常，8名患者低于正常水平。这8名患者在调查时叶酸处于负平衡状态。使用RP VI透析器进行透析的7名患者，叶酸最大丢失量为75微克/次透析；6名进行慢性间歇性腹膜透析的患者，叶酸最大丢失量为13微克/次透析。因此，只要每日膳食叶酸摄入量充足，慢性透析的尿毒症患者无需口服补充叶酸。
