Bhanji S, Lader M
Eur J Clin Pharmacol. 1977 Dec 16;12(5):349-54. doi: 10.1007/BF00562450.
Ten patients with psychotic depression were assessed on a battery of clinical, EEG, psychological, and biochemical measures during treatment with imipramine (150 mg/day). Significant changes occurred in the scores on self-rated and observer-rated depression scales and on an observer-rated side effect scale. Significant changes also occurred in the EEG evoked response, but the effects on spontaneous activity were minimal. The psychological measures revealed an improvement in performance as treatment progressed. The clinical significance of the changes observed was assessed with reference to their correlations with the clinical rating scores and with the plasma concentrations of imipramine and desmethylimipramine, and the changes observed following the administration of imipramine to non-depressed normal subjects. Changes in evoked EEG activity seemed on balance to be direct central effects of imipramine, whereas changes in psychological performance appeared to be secondary to clinical change.
对10例患有精神病性抑郁症的患者在接受丙咪嗪（150毫克/天）治疗期间，进行了一系列临床、脑电图、心理和生化指标的评估。自评和他评抑郁量表以及他评副作用量表的得分出现了显著变化。脑电图诱发反应也发生了显著变化，但对自发活动的影响极小。心理测量结果显示，随着治疗进展，患者的表现有所改善。通过将观察到的变化与临床评分、丙咪嗪和去甲丙咪嗪的血浆浓度之间的相关性，以及对非抑郁正常受试者给予丙咪嗪后观察到的变化进行参考，评估了所观察到变化的临床意义。脑电图诱发活动的变化总体上似乎是丙咪嗪的直接中枢效应，而心理表现的变化似乎继发于临床变化。
