Mohabbat O, Younos M S, Merzad A A, Srivastava R N, Sediq G G, Aram G N
Lancet. 1976 Aug 7;2(7980):269-71. doi: 10.1016/s0140-6736(76)90726-1.
Following a 2-year period of severe drought a very large number of patients with massive ascites and emaciation were observed in north-western Afghanistan. Clinicopathological study showed that these were typical cases of hepatic veno-occlusive disease. The outbreak was caused by consumption of bread made from wheat contiminated with seeds of Heliotropium plants, which were shown to contain pyrrolizidine alkaloids. Examination of 7200 inhabitants from the affected villages showed evidence of liver disease in 22.6%. Clinical improvement was observed in thirteen cases after 3 to 9 months of supportive hospital treatment, and in three cases liver biopsies showed almost complete disappearance of initial abnormalities.
在经历了两年的严重干旱之后，阿富汗西北部出现了大量患有大量腹水和消瘦的患者。临床病理研究表明，这些是典型的肝静脉闭塞病病例。疫情是由食用用被天芥菜属植物种子污染的小麦制成的面包引起的，这些种子被证明含有吡咯里西啶生物碱。对受影响村庄的7200名居民进行检查发现，22.6%的人有肝病迹象。在接受了3至9个月的支持性医院治疗后，13例患者的临床症状有所改善，3例患者的肝脏活检显示最初的异常几乎完全消失。
