Johnson R E, Brereton H D, Kent C H
Lancet. 1976 Aug 7;2(7980):289-91. doi: 10.1016/s0140-6736(76)90736-4.
A regimen of intensive, cyclic chemotherapy (cyclophosphamide, vincristine, doxorubicin administered concurrently with radiotherapy of bulk disease plus prophylactic whole-brain irradiation has been investigated for small-cell carcinoma of the lung. Treatment was completed in 12 weeks, after which patients were observed without maintenance therapy. Complete clinical remissions were noted in twenty of twenty-one patients with unresectable tumours, 10 of whom had distant extrathoracic spread upon admission. Survival has been prolonged and nine of the eleven patients with regional disease (mediastinal adenopathy with or without pleural effusion and/or supraclavicular nodes) have remained clinically disease-free for 6-14 months (median 10) and have resumed normal activities.
对于肺小细胞癌，已经研究了一种强化的、周期性化疗方案（环磷酰胺、长春新碱、阿霉素与大块病灶放疗同时进行，加预防性全脑照射）。治疗在12周内完成，之后对患者进行观察，不进行维持治疗。21例不可切除肿瘤患者中有20例实现了完全临床缓解，其中10例入院时已有远处胸外转移。生存期得到延长，11例局部病变（有或无胸腔积液和/或锁骨上淋巴结的纵隔淋巴结肿大）患者中有9例临床无病生存6 - 14个月（中位值10个月），并已恢复正常活动。
