Ukida M, Shimada Y
Gastroenterol Jpn. 1977;12(5):368-79. doi: 10.1007/BF02774534.
The clinical course and prognosis of hepatic coma were examined in 102 patients treated in the period from 1958 to 1975. The diagnoses included 9 fulminant hepatitis, 7 subacute hepatitis, 53 liver cirrhosis without liver carcinoma (40 cases of the acute type, 10 cases of the chronic type and 3 cases of another type, according to Sherlock's classification of hepatic coma) and 33 liver cirrhosis with primary liver carcinoma. Four of 9 fulminant hepatitis patients gained consciousness within 1 week and recovered completely. Seven subacute hepatitis patients died within 2 weeks after onset of hepatic coma. In the period from 1958 to 1969, 20% of liver cirrhosis patients with the acute type of coma recovered from coma, and in the period from 1970 to 1975, 45% of patients recovered. Seven of 10 patients with the chronic type of coma died between 4 months and 9 years after the onset of coma. Three other patients are presently still alive. The median survival time was 2.5 years. Nine primary liver carcinoma patients with coma were hospitalized from 1958 to 1969 and 24 from 1970 to 1975. Hepatorenal syndrome was present in 31 of 71 examined patients. Twenty-three patients with hepatorenal syndrome were in the period from 1970 to 1975.
对1958年至1975年期间接受治疗的102例肝昏迷患者的临床病程和预后进行了研究。诊断包括9例暴发性肝炎、7例亚急性肝炎、53例无肝癌的肝硬化（根据夏洛克肝昏迷分类，急性型40例，慢性型10例，另一类型3例）以及33例伴有原发性肝癌的肝硬化。9例暴发性肝炎患者中有4例在1周内恢复意识并完全康复。7例亚急性肝炎患者在肝昏迷发作后2周内死亡。在1958年至1969年期间，急性型昏迷的肝硬化患者中有20%从昏迷中康复，在1970年至1975年期间，45%的患者康复。10例慢性型昏迷患者中有7例在昏迷发作后4个月至9年之间死亡。另外3例患者目前仍然存活。中位生存时间为2.5年。9例昏迷的原发性肝癌患者于1958年至1969年住院，24例于1970年至1975年住院。71例接受检查的患者中有31例出现肝肾综合征。23例出现肝肾综合征的患者处于1970年至1975年期间。
