Ortmans H, Wildhirt E
Dtsch Med Wochenschr. 1975 Apr 11;100(15):812-4. doi: 10.1055/s-0028-1106300.
114 patients with cryptogenic or "hepatitic" cirrhosis of the liver (toxic or biliary causes excluded) were followed for a period of 15 years. The time of first manifestation of the disease was known because all patients had been in hospital or under serial outpatient observation, with clinical and biopsy studies every six months for chronic hepatitis. In addition, diagnosis of the liver cirrhosis was confirmed by laparoscopy and histomorphology, which further confirmed the exact timing of first manifestation. In 37 patients (32.5%) the disease healed out completely by way of reactionless fibrosis after, in some of them, a long period of observation, while in 47 (41.2%) the active disease continued, and 30 (26.3%) died in liver coma or bleeding from varices or surgical shunt procedures or from carcinoma of the liver. Prognosis of cirrhosis of the liver is thus much better than previously thought.
114例隐源性或“肝炎性”肝硬化患者（排除中毒或胆汁淤积性病因）接受了为期15年的随访。由于所有患者均住院或接受连续门诊观察，每6个月进行慢性肝炎的临床及活检研究，因此疾病首次出现的时间是已知的。此外，肝硬化的诊断通过腹腔镜检查和组织形态学得以证实，这进一步确定了首次出现的确切时间。37例患者（32.5%）在经过一段时间的观察后，通过无反应性纤维化完全康复，47例（41.2%）疾病仍处于活动期，30例（26.3%）死于肝昏迷、静脉曲张破裂出血、外科分流手术或肝癌。因此，肝硬化的预后比之前认为的要好得多。
