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[小鼠骨髓二倍体细胞和四倍体细胞中辐射诱导的结构突变谱的比较分析]

[Comparative analysis of the spectrum of radiation-induced structural mutations in diploid and tetraploid cells of mouse bone marrow].

作者信息

Demin Iu S

出版信息

Genetika. 1977;13(9):1564-71.

PMID:598700
Abstract

A comparative analysis of the spectrum of radiation-induced mutations was carried out in diploid mouse bone marrow cells and in tetraploid cells obtained from the latter by means of colchicine treatment. It is established that solitary chromatid deletions prevail among aberrations induced at the G2--S stage. This is the difference of the spectrum of induced chromatid rearrangements in animal cells from that in plant cells. It is assumed that the differences observed are caused by the specificity of supramolecular organization of chromatin in animal and plant cells.

摘要

对二倍体小鼠骨髓细胞以及通过秋水仙碱处理从后者获得的四倍体细胞中辐射诱导突变谱进行了比较分析。已确定在G2-S期诱导的畸变中,孤立染色单体缺失占主导。这是动物细胞中诱导的染色体重排谱与植物细胞中的差异。据推测,观察到的差异是由动物和植物细胞中染色质超分子组织的特异性引起的。

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