Lil'p I G
Genetika. 1984 Feb;20(2):260-5.
No differences were found in both the baseline and mitomycin C induced levels of sister chromatid exchanges (SCE) between 101/H and C57BL/6J mice differing in chromosome mutability. An increase with the age of the spontaneous and mutagen induced SCE rates was similar in the strains compared, though instability of chromosomes was much higher in old 101/H than in C57BL/6J mice. Thus, no correlation was observed between chromosomal aberration and SCE levels in these strains. As 101/H mice were recently found to be DNA repair-deficient, possible connection of SCE and repair is discussed.
在染色体突变性不同的101/H小鼠和C57BL/6J小鼠之间，无论是基线水平还是丝裂霉素C诱导的姐妹染色单体交换（SCE）水平均未发现差异。在所比较的品系中，自发和诱变诱导的SCE率随年龄的增加情况相似，尽管老龄101/H小鼠的染色体不稳定性比C57BL/6J小鼠高得多。因此，在这些品系中未观察到染色体畸变与SCE水平之间的相关性。由于最近发现101/H小鼠存在DNA修复缺陷，因此讨论了SCE与修复之间可能的联系。
